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As mentioned above, copper can generate an excess of OH during the switching between Cu + and Cu2 + states, leading to oxidative stress that underlines different known forms of regulated cell death

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The reduction of vitamin K to VKH 2 is also mediated by VKOR or an alternative warfarin-resistant pathway, catalysed by NAD(P)H-dependent vitamin K reductase activity 3,23 (Extended Data Fig