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A reduction in expression of proteins like claudin-5 and Occludin involved in the formation of BBB TJs and various markers such as IL-8 and metalloproteinase 1 tissue inhibitor are related to increased BBB permeability, which have been observed in HD patients [114, 115]

10.1128/MCB.21.12.3862-3875.2001 [DOI] [PMC free article] [PubMed] [Google Scholar] Plyasova AA, Zhdanov DD (2021) Alternative splicing of human telomerase reverse transcriptase (hTERT) and its implications in physiological and pathological processes

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There is evidence of a relationship between lipid metabolism in the brain and the development of AD [55]

Neurotoxin protection: An explorative study involving 30 individuals experiencing alcohol delirium demonstrates that those administered Semax show potential resistance to the neurotoxic effects of alcohol intoxication [18]