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Treatment with CoPP (Cobalt Protoporhyrin), a synthetic analog of heme that induces HO-1 without competing for its catalytic site, led to upregulation in both basal (Figure 2A) and post-IRI HO-1 mRNA levels (Figure 2B) that led to decreased IRI overall, evidenced by decreased post-IRI serum transaminases

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Ellis et al