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Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Cheng and Ristow, 2013), steroid hormone biosynthesis, removal of ammonia, integration of metabolic and signaling pathways for cell death and autophagy (Hammerman et al., 2004

Ethics statement The study involving animals was reviewed and approved by the Ethics Committee on Animals Experimentation Pays de Loire (accreditation number 3455)

Human clinical trial data remains limited, but ongoing studies continue to explore their therapeutic promise and optimization potential

Firstly, GSH depletion with BSO greatly sensitizes this pathway as evidenced by the unveiling of SOCE after the stimulation of G q -linked P 2 Y receptors

Ammar et al