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Med., 71: 99-104, 107-108

The conversion of malate to pyruvate is an NADPH-producing reaction, raising the possibility that the increasing pyruvate levels during storage in G6PD-deficient RBCs (Figure 6) are not only due to conversion from PEP during glycolysis, but may also be a by-product of NADPH formation from malate
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Most see changes between 2 and 6 weeks
