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The former can be detected using inductively coupled plasma-MS or calcein AM quenching, as well as other specific iron probes (Hirayama and Nagasawa, 2017

This regulatory status reflects the absence of completed human clinical trials establishing safety and efficacy to approval standards

In contrast, suicidal NETosis is a well-established mechanism that results in the death of neutrophils and is critical for host defense against infections

The method according to any one of claims 59-72, wherein said immunoconjugate or antibody is administered in a pharmaceutical composition comprising a pharmaceutical acceptable carrier