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For example, melatonin can not only directly clean ROS but also promote antioxidant enzymes such as GPx and glutathione reductase, thereby indirectly scavenging ROS

Hamadi SA, Mohammed MM, Aljaf AN, Abdulrazak A

Since it is present within the cells, it offers cells and its fragile structures first-hand protection from oxidative damage

10.1080/10408347.2017.1400423 133 SingalG.MillerP

Adipokines secreted by dysfunctional adipose tissue, particularly molecules such as leptin and adiponectin, increase inflammation [183]
