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The most severe conditions associated with defects in the axis may cause a loss of adult height of approximately 1/3 and may cause severe developmental and neurological deficits and compromise pubertal maturation and fertility

In contrast, if aberrant cancer-related genes are already present in germ cells, the lifetime risk for endometrial cancer increases, and approximately 5 % of cases of endometrial cancer are thought to be caused by a genetic predisposition

Michelle Z

These organisms are also capable of converting (3 R ,3 R )-zeaxanthin to (3 S ,3 S )-AX, which has the same optical configuration due to pre-existing C3 and C3 hydroxylation (Supplementary Figure S4) [290]