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Higher doses (15002500 mcg) are sometimes used for individuals with absorption issues, metabolic demands, or deficiency-related symptoms such as fatigue, neuropathy, or cognitive changes

Chen Z, Inague A, Kaushal K, Fazeli G, Schilling D, Xavier da Silva TN, et al

Coordination of growth with cell division in the yeast Saccharomyces cerevisiae

49:22692278 Tiranti V, D'Adamo P, Briem E, Ferrari G, Mineri R, Lamantea E, Mandel H, Balestri P, Garcia-Silva M-T, Vollmer B, Rinaldo P, Hahn SH, Leonard J, Rahman S, Dionisi-Vici C, Garavaglia B, Gasparini P, Zeviani M (2004) Ethylmalonic encephalopathy is caused by mutations in ETHE1, a gene encoding a mitochondrial matrix protein

Acknowledgements JS is supported by grant K01-MH125906 from the National Institutes of Mental Health