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Although p53 induced apoptosis via PUMA and NOXA and cell senescence via p21 play critical roles in preventing cells from malignant transformation, these two mechanisms are dispensable for p53-mediated suppression of spontaneous tumour development

[DOI] [PMC free article] [PubMed] [Google Scholar] 572

Biotechnol Adv

Nature 472 , 476480 (2011)

The integrity of your entire project hinges on getting these small, seemingly minor details right
