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Interestingly, silencing of SLC1A5 does not suppress the proliferation of epithelial cervical cancer and osteosarcoma cells

Although ESCC originates from the upper digestive tract and its metabolic features cannot be directly extrapolated to intestinal cancers, these findings suggest that serine deprivation may suppress tumor cell proliferation by limiting purine nucleotides and NADPH synthesis

Management and Prevention Strategies for Non-communicable Diseases (NCDs) and Their Risk Factors

For this purpose, the phosphate buffer of pH 6.8, 7.4, and pH 1.2 acidic buffer was used as a dissolution medium

PMID 19451637