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Aldehydes originating from lipids exhibit high reactivity, leading them to readily engage with proteins to create Michael adducts, commonly referred to as advanced lipoxidation end products (ALEs) [Frijhoff et al ., 2015]

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Although this alanine is not a conserved site in the XPD helicase family, the residue is near the fourth highly conserved cysteine residue in the ISC

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