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An HDACi that does not target HDAC5 or HDAC2 may limit side effects if inhibition is not required for transcriptional upregulation of the G6PD gene
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DNA methylation signatures link prenatal famine exposure to growth and metabolism
In line with this observation, the 37% of lung adenocarcinoma cases that present elevated expression of ser/gly synthesis enzyme genes displayed worse overall survival rates as compared to the 63% of lung adenocarcinoma cases with low expression of ser/gly synthesis enzymes genes ( n = 187 and n = 320, respectively, p = 0.004 , q = 0.0177) (Fig
10 , 521531a (2007)
