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found that the abnormal accumulation of double-stranded DNA in the cytoplasm may bind to the cytoplasmic DNA sensor (cGAS), thereby specifically triggering the STING-interferon (IFN) signaling pathway in microglia, promoting the expression and secretion of inflammatory cytokines
Iron negatively influences the process of bone homeostasis and disrupts the proliferation capacity and differentiation balance of BMSCs
These findings suggest that energy stress exerts inhibitory and promoting effects during ferroptosis, but the detailed mechanism remains unclear
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