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Almas et al
10.3390/ijms21082991 27
and there are few interventions to restore the functional neuron circuitries (5, 6)
MANF offers neuroprotection by inhibiting NF-B during ER stress and activating the AKT/GSK3-Nrf2 axis, reducing TNF- and IL-6 and slowing neurodegeneration [257]
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