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Some studies suggest that very long-term use (years of high doses) could potentially lower zinc levels

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[DOI] [PMC free article] [PubMed] [Google Scholar] 149.Feng D., Guo B., Liu G., Wang B., Wang W., Gao G., Qin H., Wu S

In addition, epithalon delivered by injection may occasionally cause inflammatory reactions surrounding the injection site

[0037] Various kits are also described to facilitate the coordinated use of toothpastes in accordance with the present invention and/or to improve the overall experience of the user and these kits may include, without limitation: multiple tubes of different toothpaste formulations