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Here, we discuss the relationship and related pathophysiologic mechanisms between TMAO and AS, as well as the potential therapeutic strategies that target these pathophysiologic mechanisms

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For example, studies on the intestinal flora of patients with prehypertension and hypertension have found that the most significant characteristics are the reduction and uneven distribution of microbial diversity and abundance, mainly manifested in the increase of Firmicutes / Bacteroidetes ratio, the decrease of probiotics, and the increase of Prevotella and Klebsiella (26)

It binds to fatty acids to form the "acyl-carnitine" , a complex capable of crossing the inner mitochondrial membrane via a specialized transport system (the carnitine shuttle or carnitine shuttle )
