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Moreover, eIF2 phosphorylation promotes the induction of autophagy, which is key for controlling HSV-1 infection in neurons (OConnell and Liang, 2016), in contrast to epithelial cells, where an IFN response is sufficient to control the infection and autophagy is not required (Yordy et al., 2012)

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In addition, there are still many problems with nanoparticle drug therapies targeting immune cells for tumors, including but not limited to the following: (1) A large number of products are difficult to reproduce due to the synthesis and post-modification procedures of nanoparticles, especially highly engineered nanoparticles, and this also result in increased costs (246)

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