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After transient MCAO, CD163 macrophages upregulated the expression of the hypoxia-inducible factor-1 (HIF-1) pathway, vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), and chemoattractants, leading to neurological impairment [125, 126]

Patients being treated with tesofensine also displayed the following positive results: Improved levels of insulin sensitivity, higher metabolism of glucose, potentially suitable for patients at risk from type II diabetes

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