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10.1371/journal.pone.0021876 52 WilsonP

CSD is characterized by a propagating wave of neuronal and glial depolarization driven by significant ion movements across the cortex, which subsequently results in prolonged suppression of neuronal activity

653 The precursor must also be kinetically competitive against the native substrate present at intracellular concentrations

It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models