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Overall, GS-16-OPT exhibited slightly higher release at intestinal pH compared to GS-12-OPT

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This led to the development of compounds irreversibly interacting with EGFRm/T790M, such as afatinib, 324674 and more recently AZD9291 and CO1696 [1012]

1 2 "ESA's Mars and Jupiter missions observe comet 3I/ATLAS"

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