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Tian-Lei Ying of the Key Laboratory of Medical Molecular Virology of MoE & MoH, Shanghai Medical College, Fudan University for preparing the figure

Mol Cell Proteomics

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Nausea management strategies include eating smaller meals, avoiding high-fat foods around injection time, staying well-hydrated, and taking the injection at a time that positions peak nausea during sleep hours

The standard approach involves: Starting at 2.5 mg weekly for at least four weeks Increasing by 2.5 mg increments at four-week intervals Delaying dose escalation if gastrointestinal symptoms are problematic Recognizing that slower titration, while extending the time to reach therapeutic doses, may improve long-term adherence Injection Technique Optimization can reduce local reactions: Rotating injection sites (abdomen, thigh, upper arm) Allowing the medication to reach room temperature before injection Using proper technique to minimize tissue trauma Hypoglycemia Prevention requires careful attention when tirzepatide is combined with other glucose-lowering medications