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But consistent with other trials, neutralizing antibodies against ADI-PEG20 was observed in some patients in later part of treatment, leading to resistance [139]

Animal Biotechnology 14: 19-29.CrossRefGoogle ScholarPubMed LI, J.L

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(2006) have presented a newer model for the catalytic reaction in which Glu146 functions as a general base, accepting a proton from zinc-bound water and shuttling the proton to the leaving group facilitating breakdown of the tetrahedral intermediate