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They then mature within the microenvironment of various tissues, including the vascular endothelium and the brain, where they participate in both innate and adaptive immune responses, even in the absence of antigen presentation (Dong et al., 2014b)

R.RastegarT.NoorbakhshF.et al

DOI: 10.1007/s00210-023-02677-1

137 OkoroiwuH

By contrast, activation of EPACs is sufficient to impair LepRb signalling with concomitant induction of SOCS3 and also blunts leptin-induced depolarization of hypothalamic POMC neurons
