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(5) A Nakamura, M Nakashima, T Sugao, H Kanemoto, et al (1988) Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP) European Journal Pharmacology, 1988 Oct 18, Volume 155 (Issue 3), Pages 247-53

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Another study revealed that 77% of men and 80% of postmenopausal women developed organ dysfunction under choline deprivation, while less than half of premenopausal women did, highlighting the possible protective role of estrogen in choline deficiency

Both cases are very bad endpoints

Peptides as therapeutic agents: why medical supervision is important Despite the promising nature of this field, peptides are not cosmetic supplements but biologically active agents