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A 2024 study achieved 3.8 greater colonic accumulation at significantly lower doses through prodrug nanoparticle engineering a development that points toward future clinical formulations with substantially improved precision.12 No standardized clinical dosing protocol exists

This distinction is critical, as even a biologically promising compound may become clinically harmful when delivered through nonstandardized formulations

STING-mediated intestinal barrier dysfunction contributes to lethal sepsis

In a recent proof-of-concept study performed in 40 patients with IBS, we showed that Lactobacillus paracasei CNCM I-1572 improves IBS symptoms through a significant reduction in genus Ruminococcus associated with a reduction of IL-15, linked with the modulation of IEB, and a significant increase in the fecal SCFAs acetate and butyrate (201)