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Personalized assessments determine if intervention is needed

Moreover, ROS can also react with nitric oxide to form reactive nitrogen species (RNS) like peroxynitrite, which further contribute to oxidative stress and disrupt nitric oxide-mediated signaling (Brown and Borutaite 2006)

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The most common diagnostic tool is the patch test, where small amounts of cobalt are applied to the skin under adhesive patches

doi: 10.3390/ijms12085213
