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The liver can store the vitamin for a long time, so it may take a few years for deficiency and symptoms to develop

In nature, vitamin B12 is primarily found in fish, meat, eggs, and dairy

New data from the Human Nutrition Research Center on Aging in Boston show that elderly persons with a genetic variant in the transcobalamin gene TCN2 (transcobalamin 776CG) who consume high amounts of folate (twice the RDA of 800 g Dietary Folate Equivalents), mostly due to supplements containing folic acid, are 7 times more likely to have neuropathy (38)

That becomes the reference range