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Rosenfeld, MD Genetic causes of growth failure can be broadly divided into 5 categories: chromosomal defects such as Down syndrome and Turner syndrome, inborn metabolic defects, osteochondrodysplasias, genetic defects of the thyroid axis that result in neonatal or childhood hypothyroidism, and genetic defects of the growth hormone (GH)/ insulin-like growth factor-I (IGF-I) axis

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In colorectal cancer, the HMGB1-RAGE axis promotes autophagy via ERK-mediated phosphorylation of Drp1, a mechanism contributing to both chemoresistance and tumor cell regeneratio [235]

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