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Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain

Cell Biochem Biophys 67: 477483, 2013 [DOI] [PMC free article] [PubMed] [Google Scholar] 9

In addition to energy production, mitochondria influence critical cellular functions, including differentiation, proliferation, and maintenance of homeostasis (43)

As a result, these patients can become easily overwhelmed or distracted, due to the inability of their CNS to filter out irrelevant information - this process is known as sensorimotor gating (Winship et al., 2019)

Epilepsy and movement disorders: A severe deficiency caused by rare mutations in the PNPO enzyme can result in encephalopathy, epilepsy, and movement disorders from infancy
