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Examining the expression of clock proteins at 4-hour intervals over a 24-hour period and their subcellular localisation during the light (10am) and the start of the dark period (6pm), revealed that BMAL1 expression was highest during the light period (6am-2pm) ( Figure 3A ), which corresponded with the nuclear localisation of BMAL1 at 10am ( Figure 5A )

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However, some patients continue to experience persistent symptoms even after haematological correction, highlighting the need for ongoing research and individualised management

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Modern neuroscience now emphasizes the significant impact of mental states on physical health, shaping processes like metabolism, immune function, and the activity of various organs [3]