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When inflammation becomes chronic, overproduction of reactive oxygen species (ROS) such as superoxide (O 2 ) and hydrogen peroxide (H 2 O 2 ) can be observed [3]

2023;455 doi: 10.1016/j.cej.2022.140848

Availability of data and materials No datasets were generated or analysed during the current study

Excluding the trial judged at high risk of bias for efficacy outcomes likewise did not materially change the estimate (SMD 1.32, 95% CI 2.33 to 0.31

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