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Pharmacological approaches to target/modulate CD38 The identification of CD38 as a key enzyme involved in NAD metabolism, cell signaling, and cancer suggests its potential as a target for multiple conditions

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Patients with a history of severe gastrointestinal disease, particularly those with inflammatory bowel disease, severe gastroesophageal reflux disease, or history of pancreatitis, require careful evaluation before considering this therapy

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These investigations remain confined strictly to laboratory research contexts and do not represent approved therapeutic use