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Reactive oxygen species, not Ca(2+), mediates methotrexate-induced autophagy and apoptosis in spermatocyte cell line

& Wolchok, J

Sieradzki, J

[8] Regulation of acid-base balance in the kidney by producing ammonium [9] Cellular energy, as a source, next to glucose [10] Nitrogen donation for many anabolic processes, including the synthesis of purines [7] Carbon donation, as a source, refilling the citric acid cycle [11] Nontoxic transporter of ammonia in the blood circulation

Authors noticed that, treatment with EP-1 led to an increase in antioxidant markers, improvementsin mitochondrial function, and a reduction in apoptosis in the colon epithelium