glutathione metabolism iron Role of iron, and lipid peroxidation in ferroptosis. Arrows Schematic representation of the ferroptosis
Description
Burg, K
2d-f) and weighted (Supplementary Fig
GPx4 is unique as a monomer, exhibiting broad substrate specificity and subcellular distribution, and specializes in reducing lipid peroxides and protecting cellular membranes from peroxidative damage [3, 4]
Therefore, analyzing the pathogenesis of diseases at the genetic level and developing a personalized treatment plan may offer the possibility of a permanent cure for rare and currently incurable genetic diseases
Nature 642 , 458466 (2025)
