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Multivariate analysis revealed some predictive factors of 90 th -day poor clinical outcomes, including older age (OR 1.12, p = 0.007), male sex (OR 14.56, p = 0.023), predominant hemisphere lesion (OR12.30, p = 0.026), increased NIHSS of 2 points (OR 34.47, p = 0.006), and large artery atherosclerosis classification (OR 13.08, p = 0.016)

This small molecule compound was developed through sophisticated structure-guided design and binding calculations as part of a systematic effort to create membrane-permeable NNMT inhibitors with enhanced potency and selectivity

doi: 10.3389/fphys.2019.01407 Received 27 July 2019 Accepted 31 October 2019 Published 22 November 2019 Volume 10 - 2019 Edited by Thomas Similowski, INSERM U1158 Neurophysiologie Respiratoire Exprimentale et Clinique, France Reviewed by Gaspard Montandon, University of Toronto, Canada