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Such events can precipitate extensive cardiomyocyte death, resulting in pronounced cardiac function deterioration and, in severe cases, life-threatening complications ( Myocardial ischemia constitutes the predominant mechanism underlying CHD pathophysiology and serves as the central pathological process

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In addition to the role mentioned above in the process of oxidative stress, the GPX family also plays a unique role in tumor development (Laribi et al., 2021), viral infection (Strycharz-Dudziak et al., 2020), obesity (Rusetskaya et al., 2019), signal transduction, and inflammation (Rusetskaya et al., 2019)