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Alternatively, P53 enhances the sensitivity of cells to ferroptosis by enhancing the expression of spermidine/spermine N1-acetyltransferase 1 (SAT1) and glutaminase 2 (GLS2) and inhibiting cystine uptake [101,102,103]

Lymphadenopathy or hepatosplenomegaly suggest an underlying lymphoproliferative disorder or malignancy

Consistent with the observation in peripheral tissues such as the adipose tissue, chronic glargine-induced nuclear localization of HIF1 in conjunction with nuclear monomeric PKM2, which facilitated a robust nuclear HRE binding in the central nervous system (i.e., cerebellum and cerebral cortex) (Fig

Papadakis G, Kandaraki EA, Garidou A, Koutsaki M, Papalou O, Diamanti-Kandarakis E, Peppa M

2.2.6 A circRNA that induces ferroptosis by upregulating zinc and ring finger 3 (ZNRF3) The tumor suppressor circ_0000190 sponges miR-382-5p and suppresses cell proliferation and motility and promotes cell death by targeting ZNRF3 in GC cells (Jiang et al., 2022)