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we can presume that deletions causing frameshifts would be lethal

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doi: 10.1002/mco2.70116 13 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

The five vertebrae in your lumbar spine are named lumbar 1 (L1) through lumbar 5 (L5) from top to bottom

[PubMed] [Google Scholar] Adachi H., Katayama T., Inuzuka C., Oikawa S., Tsujimoto M., Nakazato H
