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The blood-brain barrier (BBB) represents a major hurdle to drug delivery to brain tumours

The mechanisms are complementary, making this combination theoretically rational

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Preclinical studies indicate mild tolerance in animal models

360 In subsequent studies it was determined that GA-binding proteins alpha and beta mediate induction of the CD18 gene, 369 activator protein 1, specificity protein 1 and Pur mediate induction of the CD11c gene, 368,371 myeloid specificity 2 and Pur mediate induction of the CD11a and CD11b genes, 262,370 and Pur mediates induction of the CD11d gene