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For peptideswhere dosing is measured in micrograms and administration is typically subcutaneous injectioncompounding quality directly determines clinical safety

Gorringe, KL, George J, Anglesio MS, Ramakrishna M, Etemadmoghadam D, Cowin P, et al

However, to accurately assess the screening ability of these in vitro 3D bloodbrain barrier models for nanomedicines, it is first necessary to validate their barrier function

The safety profile is strong: toxic doses sit roughly 300 to 3,750 times higher than recommended therapeutic amounts, and injection site irritation remains the most commonly reported side effect