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Sin embargo, es fundamental considerar que los efectos pueden variar entre individuos y no todos obtendrn los mismos resultados esperados

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Activity at mu and delta receptors mediates classic opioid effects (e.g., analgesia, euphoria, sedation) while drugs that mimic the endogenous ligand for kappa receptors exert an opposite pharmacologic profile (e.g., increased pain sensitivity, dysphoria)