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One of the features of polyQ aggregation is that it induces some pathways of the UPR and the expression of genes encoding chaperones (Leitman et al , 2013

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In particular, we previously showcased that caffeine, at doses borderline for eliciting arousal [10, 11] and locomotor activity [7, 12], can functionally antagonize alcohol reinforcement by demonstrating that it could prevent the acquisition of alcohol-elicited conditioned place preference and aversion [13], pointing to the dopamine (DA)-dependent underlying associative learning process [14] as the possible mechanism targeted by caffeine to gain this behavioral outcome