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Boyle CN, Zheng Y, Lutz TA

The major classes of analgesics include nonsteroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, local anesthetics, and gabapentinoids, each operating via distinct molecular mechanisms yet converging on the suppression of nociceptive signaling at the site of tissue injury, either along peripheral nerves or within central pain-processing pathways

Following complete bAVM resection, all seizure-prone patients remained seizure-free, with post-surgery BOLD-CVR revealing an improvement of peri-nidal and whole-brain CVR towards normal levels in these patients when venous congestion was resolved