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There is a well-recognized phenomenon in gut-hormone pharmacology whereby a signal that potently slows gastric emptying on first exposure gradually loses that particular effect under continuous stimulation, even as its central appetite-suppressing effect persists

Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration

2016/03/01/ 2020;33(S1):S555-S556

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Interestingly, there is no known receptor for klotho, rather there is a coreceptor formed by shed klotho, FGFR, and FGF23, which indicates that shed klotho is an enzyme-dependent active scaffold protein