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Functionally, GDAP1 loss strongly induces a disruption of both early and late stages of autophagy, leading to altered phagophore and autophagosome morphology, accumulation of autophagosomes, impaired vesicle maturation, slowed autophagic flux, and defective vesiclelysosome fusion [12]

Interestingly, in human subjects, as well as in animal models, there appears to be a limited range for the beneficial effects of selenium: both too much and too little may have detrimental effects on health (reviewed in [21, 22])

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FIGURE 1 2.2 Metabolic disorders Metabolic disorders, including diabetes and obesity, are conditions characterized by abnormalities in the bodys metabolic processes, leading to issues like insulin resistance, increased fat accumulation, and heightened cardiovascular risk (Rochlani et al., 2017)

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