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(1) Adolescence (1218 years): high sensitivity to high-sugar diets Although human studies investigating the gut microbiome in adolescents remain limited, the ongoing development of the gut-brain axis and the adolescent brain suggests that this population may be particularly susceptible to diet-induced depressive symptoms (320), The impact of high-sugar diets on metabolic and intestinal health In male C57BL/6J mice, consumption of a high-glucose diet (HGD) over a 12-week period induces hyperglycemia, glucose intolerance, dyslipidemia, and increased adipose deposition

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The Paris criteria are most commonly used to define the presence of PBC with features of AIH [292] and have been endorsed by EASL and AASLD (98) [294]

Fer-1, a potent inhibitor of ferroptosis, acts via lipid peroxidation

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