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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Ni XP, Butler AA, Cone RD, Humphreys MH

Bioavailability of oral formulations is typically 1-3% compared to near 100% for subcutaneous injection

Higher-dose oral B12 (e.g., 1000 g daily) is sometimes used but should only be considered under clinical supervision with appropriate monitoring, particularly in cases of malabsorption where intramuscular treatment remains the first-line approach in UK practice

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Efficacy: While all medications have semaglutide as an active ingredient, Wegovy is FDA-approved for weight loss and has higher efficacy than Rybelsus at the maximum dose