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4.4 Mitophagy-driven pulmonary injury In the pathological progression of DM, aberrant accumulation of AGEs disrupts mitophagic homeostasis, thereby exacerbating multi-organ damage (Dewanjee et al., 2022

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MEVs can contain antigens that activate Toll-like receptors on epithelial or immune cells and increase blood-brain-barrier (BBB) permeability, thus facilitating the entry of bacterial byproducts in the brain (26, 29)
