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Dendritic cell subsets in T cell programming: location dictates function

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By acting as an electron donor, glutathione reduces any disulfide bond formed within cytoplasmic proteins to cysteines

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Thus, iron-metabolic dysregulation promotes EMT, which in turn exacerbates iron imbalance, establishing a self-reinforcing positive-feedback loop that drives relentless IPF progression and fibrotic remodeling (Figure 2, which highlights the key molecular drivers and the self-reinforcing feedback loop between iron dysregulation, oxidative stress, and EMT